Academic-industrial partnership to develop and test esophageal
cancer imaging tools
Agency: NIH R01
Collaborators: Rebecca Richards-Kortum (Rice), Sharmila Anandasabapthy (Mt. Sinai Medical Center), Stephen Zlock (Pentax), and Manoop Bhutani and Dipen Maru (UTMDACC)
The goal of this proposal is to develop, optimize and validate novel multi-modal, multi-scale optical imaging platforms for non-invasive, early detection of esophageal neoplasia based on optical imaging. We will collaborate with colleagues at Pentax, Inc. to design and test multi-modal endoscopic imaging systems for early detection of neoplasia in Barrett’s esophagus. Widefield endoscopic imaging will be used initially to screen the surface area at risk to identify abnormal sites with high sensitivity; suspicious areas will then be imaged with much higher spatial resolution to achieve high diagnostic specificity. Both widefield and high-resolution technologies will be integrated into a single endoscopic platform to increase the ease and accuracy of endoscopic cancer screening and surveillance. In sequential clinical studies, we will first separately optimize the performance of widefield endoscopic imaging and high-resolution imaging. We will then integrate the widefield and high-resolution imaging systems and validate their accuracy for the detection of neoplasia in subjects with Barrett’s esophagus, the precursor to esophageal adenocarcinoma. Lastly, we will develop an image atlas of typical wide-field and high-resolution images, interpretation criteria, and histopathology to train future users and serve as an educational resource.