Rice University logoDr. Rebecca Richards-Kortum
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Optical Spectroscopy and Imaging Laboratory

High Resolution Imaging & HPV Oncoprotein Detection for Global Prevention of Cervical Cancer

Agency:  NCI / NIH
Collaborators:  Rebecca Richards-Kortum (Rice), Tomasz Tkaczyk (Rice), Kathleen Schmeler (UTMDACC), Phil Castle (AECOM), Mauricio Maza (Basic Health International), Miriam Cremer (Cleveland Clinic)

Cervical cancer continues to be the 1st or 2nd leading cause of cancer death among women in low- and middle- income countries.  In resource-limited settings in the U.S. and abroad, there is a significant need for new point-of-care diagnostics that enable combined detection and treatment of cervical precancer in a single visit.  We hypothesize that a combination of imaging and biomarker detection can reduce th high false positive rate of current screening tools.  We will adapt our high-resolution microendoscope (HRME) to a mobile platform which incorporates a cell phone to capture, display, analyze, and transmit images.  We will then evaluate the performance of the mobile HRME (mHRME) with an existing biomarker (HPV DNA testing) and an investigational biomarker (HPV E7 oncoprotein).  We will evaluate the performance of the mHRME in two globally relevant contexts.  And then we will develop a rapid, low-cost, lateral flow test to detect E7 and assess test performance using cervical specimens.