1996 - 1999 Publications

Fluorescence Spectroscopy of the Cervix: Influence of Acetic Acid, Cervical Mucus, and Vaginal Medications. Agrawal A, Utzinger U, Brookner C, Pitris C, Mitchell MF, and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 25, 237-249, 1999.

Report of the Advisory Council on Optical Technologies. Bigio I, Shtern F, Ascher S, Andrews R, Bohorfush A, Brezinski M, Fujimoto J, Lam S, Mulshine J, Richards-Kortum R, Svanberg K, Tadir Y, and Tromberg B; Academic Radiology, Volume 6, Supplement 3, S157-S191, 1999.

Cervical Fluorescence of Normal Women. Brookner CK, Utzinger U, Staerkel G, Ricahrds-Kortum R, and Mitchell MF; Lasers in Surgery and Medicine, Vol.24, 29-37, 1999.

A Comparison of C/B Ratios from Studies Using Receiver Operating Characteristic Curve Analysis. Cantor SB, Sun CC, Tortolero-Luna G, Richards-Kortum R, and Follen M; J Clin Epidemiol, Vol. 52, No. 9, 885-892, 1999.

Light scattering from cells: finite-difference time-domain simulations and goniometric measurements. Drezek R, Dunn A, and Ricahrds-Kortum R; Appliced Optics, Vol. 38, No. 16, 3651-3661, 1999.

Fluorescence Spectroscopy for Diagnosis of Squamous Intraepithelial Lesions of the Cervix. Mitchell MF, Cantor SB, Ramanujam N, Tortolero-Luna G, and Richards-Kortum R; Obstetrics & Gynecology, Vol. 93, No. 3, 462-470, 1999.

Screening for Squamous Intraepithelial Lesions with Fluorescence Spectroscopy. Mitchell MF, Cantor SB, Brookner C, Utzinger U, Schottenfeld D, and Richards-Kortum R; Obstetrics & Gynecology, Vol. 94, No. 5, Part 2, 889-896, 1999.

Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morpholoy. Sokolov K, Drezek R, Gossage K, and Richards-Kortum R; Optics Express, 5(13):302-317, 1999.

Performance Estimation of Diagnostic Tests for Cervical Precancer Based on Fluorescence Spectroscopy: Effects of Tissue Type, Sample Size, Population, and Signal-to-Noise Ratio. Utzinger U, Trujillo EV, Atkinson EN, Mitchell MF, Cantor SB, and Richards-Kortum R; IEEE Transactions on Biomedical Engineering, Vol. 46, No. 11, 1293-1303, 1999.

Resonance Raman Spectroscopy at 257 nm Excitation of Nomal an Malignant Cultured Breast and Cervical Cells. Yazdi Y, Ramanujam N, Lotan R, Mitchell MF, Hittelman W, and Richards-Kortum R; Applied Spectroscopy, Vol. 53, No. 1, 82-85, 1999.

Fluorescence Excitation Emission Matrices of Human Tissue: A System for in Vivo Measurement an Method of Data Analysis. Zuluga AF, Utzinger U, Durkin A, Fuchs H, Gillenwater A, Jacob R, Kemp B, Fan J, and Richards-Kortum R; Applied Spectroscopy, Vol. 53, No. 3, 302-311, 1999.

Spatially resolved spectral interferometry for determination of subsurface structure. Zuluaga AF, and Richards-Kortum R; Optics Letters, Vol. 24, No. 8, 519-521, 1999.

Cost-Effectiveness Analysis of Diagnosis and Management of Cervical Squamous Intraepithelial Lesions. Cantor SB, Mitchell MF, Tortolero-Luna G, Bratka CS, Bodurka DC, and Richards-Kortum R; Obstet & Gynecology, Vol. 91, 270-277, 1998.

Noninvasive Diagnosis of Oral Neoplasia Based on Fluorescence Spectroscopy and Native Tissue Autofluorescene. Gillenwater A, Jacob R, Ganeshappa R, Kemp B, El-Naggar AK, Palmer JL, Clayman G, Mitchell MF, and Richards-Kortum R; Arch Otolaryngol Head Neck Surgery, Vol. 124, 1251-1258, 1998.

Fluorescence Spectroscopy: A Technique with Potential to Improve the Early Detection of Aerodigestive Tract Neoplasia. Gillenwater A, Jacob R, Richards-Kortum R; Head & Neck, Vol. 20, 556-562, 1998.

Development of a Fiber Optic Probe to Measure NIR Raman Spectra of Cervical Tissue In Vivo. Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Utzinger U, and Ricahrds-Kortum R; Photochemistry and Photobiology, Vol. 68, No. 3, 427-431, 1998.

Near-Infrared Raman Spectroscopy for In Vitro Detection of Cervical Precancers. Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Malpica A, Thomsen S, Utzinger U, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 68, No. 1, 123-132, 1998.

Colposcopy for the Diagnosis of Squamous Intraepithelial Lesions: A Meta-Analysis. Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, and Richards-Kortum R; Obstetrics & Gynecology, Vol. 91, No. 4, 626-632, 1998.

Penetration depth limits of in vivo confocal reflectance imaging. Smithpeter CL, Dunn AK, Welch AJ, and Richards-Kortum R; Applied Optics, Vol. 37, No. 13, 2749-2754, 1998.

Near Real Time Confocal Microscopy of Cultured Amelanotic Cells: Sources of Signal, Contrast Agents and Limits of Contrast. Smithpeter CL, Dunn AK, Drezek R, Collier T, and Richards-Kortum R; Journal of Biomedical Optics, Vol. 3, No. 4, 429-436, 1998.

Method to Determine Tissue Fluorescence Efficiency in Vivo and Predict Signal-to-Noise Ratio for Spectrometers. Trujillo EV, Sandison DR, Utzinger U, Ramanujam N, Mitchell MF, and Richards-Kortum R; Applied Spectroscopy, Vol. 52, No. 7, 943-951, 1998.

Ensembles of Radial Basis Function Networks for Spectroscopic Detection of Cervical Precancer. Tumer K, Ramanujam N, Ghosh J, and Richards-Kortum R; IEEE Transctions on Biomedical Engineering, Vol. 45, No. 8, 953-961, 1998.

Safety Analysis: Relative Risks of Ultraviolet Exposure from Fluorescence Spectroscopy and Colposcopy Are Comparable. Brookner CK, Agrawal A, Trujillo EV, Mitchell MF, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 65, No. 6, 1020-1025, 1997.

Finite-Difference Time-Domain Simulation of Light Scattering from Single Cells. Dunn A, Smithpeter C, Welch AJ, and Richards-Kortum R; Journal of Biomedical Optics, Vol. 2, No. 3, 262-266, 1997.

Raman Spectroscopy for Cancer Detection: A Review. Mahadevan-Jansen A, and Richards-Kortum R; 19th International Conference- IEEE/EMBS, Oct. 30-Nov. 2, 1997.

Propagation of Fluorescent Light. Welch AJ, Gardner C, Richards-Kortum R, Chan E, Criswell G, Pfefer J, and Warren S; Lasers in Surgery and Medicine, Vol. 21, 166-178, 1997.

Sources of contrast in confocal reflectance imaging. Dunn AK, Smithpeter C, Welch AJ, and Richards-Kortum R; Applied Optics, Vol. 35, No. 19, 3441-3446, 1996.

Three-Dimensional Computation of Light Scattering From Cells. Dunn A and Richards-Kortum R; IEEE Journal of Selected Topics in Quantum Electronics, Vol. 2, No. 4, 898-905, 1996.

Application of The Method of Partial Least Squares to Determine Chromophore Concentrations from Fluorescence Spectra of Turbid Samples. Drukin AJ and Richards-Kortum R; SPIE, Vol. 2678, 475-484, 1996.

Comparison of Methods to Determine Chromophore Concentrations From Fluorescence Spectra of Turbid Samples. Durkin AJ and Richards-Kortum R; Lasers in Surgery and Medicine, Vol. 19, 75-89, 1996.

Raman Spectroscopy for the Detection of Cancers and Precancers. Mahadevan-Jansen A and Richards-Kortum R; Journal of Biomedical Optics, Vol. 1, No. 1, 31-70, January 1996.

Cervical Human Papillomavirus Infection and Intraepithelial Neoplasia: a Review. Mitchell MF, Tortolero-Luna G, Wrtight T, Sarkar A, Richards-Kortum R, Hong WK, Schottenfeld D; Journal of the National Cancer Institute Monographs, Vol. 21, 17-25, 1996.

Cervical Precancer Detection Using a Multivariate Statistical Algorithm Based on Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths. Ramanujam N, Mitchell MF, Mahadevan-Jansen A, Thomsen SL, Staerkel G, Malpica A, Wright T, Atkinson N, and Richards-Kortum R; Photochemistry and Photobiology, Vol. 64, No. 4, 720-735, 1996.

Development of a Multivatirate Statistical Algorithm to Analyze Human Cervical Tisue Fluorescence Spectra Acquired In Vivo. Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson N, and Richards-Kortum R; Lasers in Surgery and Medicine Vol. 19, 46-62, 1996.

Optical Spectroscopy vs. the Surgical Suite. Richards-Kortum R, Mahadevan-Jansen A, and Ramanjam N; Circuits & Devices, 34-40, 1996.

Spectroscopic Diagnosis of Cervical Intraepithelial Neoplasia (CIN) In Vivo Using Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths. Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson N, and Richards-Kortum R; Lasers in Surgery and Medicine Vol. 19, 63-74, 1996.

Development of A Cost-effective Optical System for Detection of Cervical Pre-cancer. Trujilo EV, Sandison D, Ramanujam N, Follen-Mitchell M, Cantor S, and Richards-Kortum R; Dept. of Electrical and Computer Engineering.