The Effectiveness of High Resolution Microendoscopy (HRME) in High Grade Intraepithelial Lesions (HSIL) Diagnosis for People Living with HIV

Funding Agency:

NIH/ National Cancer Institute


Rebecca Richards-Kortum (Rice), Sharmila Anandasabapathy (Baylor CoM), Elizabeth Chiao (UTMDACC)


Currently mobile high-resolution microendoscope (mHRME) has been utilized for esophageal and cervical squamous cell neoplasia. The existing platforms and image analysis criteria created from preliminary work for esophageal squamous cell neoplasia screening will need to be adapted to accommodate anal canal screening that can be used by clinicians trained in high resolution anoscopy (HRA). The goal of this project is to develop and optimize a) mHRME with 3D image mapping and b) image-analysis software for anal High Grade Squamous Intraepithelial Lesion (HSIL) diagnosis during HRA. We will then compare the diagnostic performance and efficiency of HRME-based HSIL diagnoses to that of HRA-guided anal biopsies. We will also develop a mathematical micro-simulation model to evaluate the cost-effectiveness of our proposed optical biopsy approach (mHRME during HRA) compared to the current gold-standard of HRA-guided biopsies.